IGF-1 LR3 1mg – 3ml Vial

Product Overview

IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) is a modified analogue of native human IGF-1. It contains an arginine substitution at position 3 and an extended 13-amino-acid N-terminal sequence, reducing binding affinity to IGF binding proteins (IGFBPs) in laboratory models.

In controlled in-vitro and pre-clinical research systems, IGF-1 LR3 is commonly utilised to investigate:

• IGF-1 receptor (IGF-1R) binding dynamics

• PI3K/Akt and MAPK intracellular signalling pathways

• Cellular proliferation signalling mechanisms

• Growth factor receptor modulation

• Structure–activity relationship studies within IGF analogues

The extended N-terminal modification enhances stability in experimental systems and alters receptor interaction kinetics compared to native IGF-1.

Supplied in lyophilised form to preserve structural integrity and analytical stability prior to reconstitution.

Key Features

• Recombinant long-acting IGF-1 analogue

• Reduced IGFBP binding affinity (LR3 modification)

• Studied in IGF-1 receptor signalling research

• Investigated in PI3K/Akt pathway models

• ≥99% purity (HPLC verified)

• Lyophilised solid for enhanced stability

• 1mg per sterile 3ml glass vial

Product Specifications

• Product Name: IGF-1 LR3

• Synonyms: Long R3 IGF-1; Recombinant IGF-1 Analogue

• Molecular Class: Recombinant polypeptide growth factor analogue

• Amino Acid Sequence (3-Letter Code):
  Arg-Gly-Pro-Glu-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr
  (Extended 13-amino-acid N-terminus with Arg substitution at position 3)

• Molecular Formula: Approx. C400H625N111O115S6

• Molecular Weight: ~9110 g/mol (approximate)

• CAS Number: 946870-92-4

• Purity: ≥99% (HPLC)

• Appearance: White to off-white lyophilised powder

• Net Content: 1mg

• Vial Size: 3ml sterile glass vial

• Storage Form: Lyophilised polypeptide

• Intended Use: Laboratory research only

Handling & Storage Guidelines

Unreconstituted (Lyophilised) Storage:
Store at −20°C for long-term preservation. Short-term storage at 2–8°C is acceptable if intended for use within 1–3 months.

Reconstituted Storage:
After reconstitution, store at 2–8°C and use within 2–4 weeks. Stability may vary depending on solvent selection and handling conditions.

Avoid repeated freeze–thaw cycles. Protect from excessive agitation, heat, and direct light exposure.

Manufacturing & Quality

IGF-1 LR3 is produced using recombinant expression and purification systems under GMP-aligned laboratory standards.

Each batch undergoes:

• High Performance Liquid Chromatography (HPLC) purity verification

• Mass spectrometry identity confirmation

• Protein integrity analysis

• Analytical quality control prior to release

• Batch traceability and documentation procedures

Products are released only after meeting strict internal quality specifications.

Legal & Safety Notice

This product is supplied strictly for laboratory research purposes only.

Not for human consumption.
Not for therapeutic, diagnostic, or veterinary use.
Not a licensed medicinal product in the United Kingdom.

The purchaser is responsible for ensuring full compliance with all applicable UK laws and regulations relating to research chemicals.